现货大促销,价格低至8折起,量大更优惠,详细咨询客服
全部分类
全部分类
  • AG-126
AG-126的可视化放大

AG-126

Tyrosine kinase inhibitor that blocks ERK1/2 phosphorylation

原价
¥687-2862
价格
550-2290
AG-126的二维码

所有产品仅用于科学研究,我们不为任何个人用途提供产品和服务

询价有惊喜,量大更优惠 点击这里给我发消息

  • 库存: 现货
可选包装 >>>
首页
  • 货号: ajci18772
  • CAS: 118409-62-4
  • 别名: 酪氨酸磷酸化抑制剂126,Tyrphostin AG-126
  • 分子式: C10H5N3O3
  • 分子量: 215.2
  • 纯度: >98%
  • 溶解度: ≤0.15mg/ml in ethanol;10mg/ml in DMSO;10mg/ml in dimethyl formamide
  • 储存: Store at -20°C
  • 库存: 现货

Background

IC50: inhibits the phosphorylation of ERK1 and ERK2 at 25-50 μM


AG-126 is an ERK1 and ERK2 inhibitor.


Extracellular signal-regulated kinases (ERKs) are widely expressed intracellular signalling molecules that are involved in functions including the regulation of meiosis, mitosis, and postmitotic functions. Many different stimuli, such as growth factors, cytokines, transforming agents, and carcinogens, can activate the ERK pathway.


In vitro: Previous study found that r AG126 ould potently inhibit the PCW-evoked release and this effect was rather selective with respect to the stimulus. AG126 was found to be less potent in attenuating LPS-triggered release. Moreover, it was found that AG126 was able to prevent the PCW-inducible ERK phosphorylation, which could relate to the AG126-mediated inhibition of PCW-evoked cytokine release [1].


In vivo: AG126 was tested in a model of PCW-induced meningitis, in which rats underwent intracisternal injection of PCW with and without AG126 pretreatment. PCW injection led to a dramatic leukocyte influx into the CSF. AG126 treatment could significantly attenuate such invasion, without changing the number of circulating leukocytes. In addition, AG126 treatment showed beneficial effects on other parameters, such as intracranial pressure. Furthermore, AG126 had no adverse effect on several physiological parameters including mean arterial blood pressure, arterial PaO2, PaCO2 as well as pH [1].


Clinical trial: So far, no clinical study has been conducted.

Reference:
[1] Hanisch, U.?K.,Prinz, M.,Angstwurm, K., et al. The protein tyrosine kinase inhibitor AG126 prevents the massive microglial cytokine induction by pneumococcal cell walls. European Journal of Immunology 31, 2104-2115 (2001).

动态评分

0.0

没有评分数据
没有评价数据
一键回到顶部
展开 收缩
安捷凯在线客服