A precursor in the biosynthesis of coenzyme A
D-Pantothenic acid (vitamin B5) is a water-soluble vitamin and is an essential nutrient to synthesize coenzyme-A, fats, proteins and carbohydrates.
D-Pantothenic acid is a water-soluble vitamin. In rabbits, pentothenate (20 mg/kg) significantly increased aponeurosis strength after surgery and improved the strength of the skin. Also, pentothenate significantly increased the fibroblast content of the scar during the fibroblast proliferation phase [1]. Pantothenic acid deficiency increased occurrence of hypertension due to adrenal regeneration [2]. In rabbits, cerebellar and forebrain slices were able to accumulate and phosphorylate pantothenic acid. However, medium-chain fatty acids, probenecid and ouabain inhibited pantothenic acid accumulation by forebrain slices and inhibited conversion to CoA [3]. In ICR mice, pantothenic acid significantly reduced valproic acid (VPA)-induced exencephaly, which suggested that pantothenic acid inhibited neural tube defects induced by VPA [4].
参考文献:
[1].? Aprahamian M, Dentinger A, Stock-Damgé C, et al. Effects of supplemental pantothenic acid on wound healing: experimental study in rabbit. Am J Clin Nutr, 1985, 41(3): 578-589.
[2].? Schwabedal PE, Pietrzik K, Wittkowski W. Pantothenic acid deficiency as a factor contributing to the development of hypertension. Cardiology, 1985, 72 Suppl 1: 187-189.
[3].? Spector R. Development and characterization of pantothenic acid transport in brain. J Neurochem, 1986, 47(2): 563-568.
[4].? Sato M, Shirota M, Nagao T. Pantothenic acid decreases valproic acid-induced neural tube defects in mice (I). Teratology, 1995, 52(3): 143-148.
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