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  • Cyclo (-RGDfK)
Cyclo (-RGDfK)的可视化放大

Cyclo (-RGDfK)

An inhibitor of αvβ3 integrin

原价
¥987-6137
价格
790-4910
Cyclo (-RGDfK)的二维码

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  • 库存: 现货
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  • 货号: ajci19462
  • CAS: 161552-03-0
  • 别名: Cyclo(-Arg-Gly-Asp-D-Phe-Lys)
  • 分子式: C27H41N9O7
  • 分子量: 603.7
  • 纯度: >98%
  • 溶解度: ≥ 30.185mg/mL in DMSO, ≥ 59.2 mg/mL in Water
  • 储存: Store at -20°C
  • 库存: 现货

Background

Cyclo(-RGDfK) is a potent and selective inhibitor of the αvβ3 integrin, with an IC50 of 0.94 nM.


Cyclo(-RGDfK) is a potent and selective inhibitor of the αvβ3 integrin, with a IC50 of 0.94 nM[1]. [(66)Ga]DOTA-E-[c(RGDfK)]2 can be prepared with high radiochemical purity (>97%), specific activity (36-67GBq/μM), in vitro stability, and moderate protein binding. MicroPET imaging up to 24 post-injection showed contrasting tumors reflecting αvβ3-targeted tracer accumulation[2].


参考文献:
[1]. Simecek J, et al. Benefits of NOPO as chelator in gallium-68 peptides, exemplified by preclinical characterization of (68)Ga-NOPO-c(RGDfK). Mol Pharm. 2014 May 5;11(5):1687-95.
[2]. Lopez-Rodriguez V, et al. Preparation and preclinical evaluation of (66)Ga-DOTA-E(c(RGDfK))2 as a potential theranostic radiopharmaceutical. Nucl Med Biol. 2015 Feb;42(2):109-14.

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