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  • Mechlorethamine HCl
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Mechlorethamine HCl

Mechlorethamine HCl 是一种对黏膜有破坏作用的发泡剂和坏死性刺激物。

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¥587-587
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470-470
Mechlorethamine HCl的二维码

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  • 货号: ajci19480
  • CAS: 55-86-7
  • 别名: 恩比兴,Mechlorethamine hydrochloride
  • 分子式: C5H11Cl2N.HCl
  • 分子量: 192.51
  • 纯度: >98%
  • 溶解度: ≥ 9.65mg/mL in DMSO
  • 储存: Store at -20°C
  • 库存: 现货

Background

Chlormethine hydrochloride is a vesicant and necrotizing irritant destructive to mucous membranes. The hydrochloride is used as an antineoplastic in Hodgkin's disease and lymphomas. Target: Chlormethine is a nitrogen mustard . It is the prototype of alkylating agents, a group of anticancer chemotherapeutic drugs. It works by binding to DNA, crosslinking two strands and preventing cell duplication. It binds to the N7 nitrogen on the DNA base guanine.


参考文献:
[1]. Cao Z, et al. Effect of brentuximab vedotin combined with chlormethine hydrochloride on the treatment of 6 patients with relapsed and refractory Hodgkin lymphoma. Zhonghua Xue Ye Xue Za Zhi. 2015 Jul 14;36(7):575-577.

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