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An IP6K and IP3K inhibitor
TNP is a cell-permeable inhibitor of IP6K1 and IP3K, with IC50 values of 0.55 μM and 10.2 μM for IP3K, respectively. TNP binds to the ATP-binding sites of both enzymes[1].
参考文献:
[1]. Chang YT, et al. Purine-based inhibitors of inositol-1,4,5-trisphosphate-3-kinase. Chembiochem. 2002 Sep 2;3(9):897-901.
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