Kif15-IN-2 是有丝分裂驱动蛋白 Kif15 的抑制剂，用于细胞增殖性疾病的研究。
Kif15-IN-2, a potent Kif15 kinesin inhibitor; inhibits cellular proliferation in various tumor cell lines [1].
Kif15,also known as Kinesin-12 and HKLP2, is a motor protein expressed in all cells during mitosis and in postmitotic neurons undergoing axon growth [2]. Kif15 is a kinesin-related protein whose mitotic homologues are believed to crosslink and immobilize spindle microtubules.KIF15 is involved in maintainingbipolar microtubulespindle apparatusin dividing cells and shares redundant functions withKIF11 [3].
参考文献:
[1].?Preparation of quinazolinediones as Kif15 kinesin inhibitors for treating cellular proliferative disorders. Pat. Appl. Publ. (2004), US 20040053948 A1 20040318.
[2].? Buster D W, Baird D H, Yu W, et al. Expression of the mitotic kinesin Kif15 in postmitotic neurons: implications for neuronal migration and development[J]. Journal of neurocytology, 2003, 32(1): 79-96.
[3].? Vanneste D, Takagi M, Imamoto N, et al. The role of Hklp2 in the stabilization and maintenance of spindle bipolarity[J]. Current Biology, 2009, 19(20): 1712-1717.
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