LP 44

A selective 5-HT7 receptor agonist

原价

￥412-1562

价格

￥ 330-1250

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库存: 现货

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产品引用

货号: ajci20466
CAS: 824958-12-5
别名:
分子式: C27H37N3OS.HCl
分子量: 488.13
纯度: >98%
溶解度: 10mg/mL in ethanol, or in DMSO, or in DMF
储存: Desiccate at -20°C
库存: 现货

Background

LP44 is a full agonist of the serotonin 5-HT7 receptor (Ki = 0.22 nM) that displays 200- and greater than 1,000-fold selectivity over 5-HT1A (Ki = 52.7 nM) and 5-HT2A (Ki = 326 nM) receptors, respectively.1 It can induce relaxation of substance P-induced guinea pig ileum contraction with an EC50 value of 2.56 μM.[1]

Reference:
[1]. Leopoldo, M., Berardi, F., Colabufo, N.A., et al. Structure-affinity relationship study on N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinealkylamides, a new class of 5-hydroxytryptamine7 receptor agents. J.Med.Chem 47, 6616-6624 (2004).

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信号通路

生命科学

有机化学

无机化学

材料科学

LP 44

LP 44详情

Background