L-Alanosine

An inhibitor of adenylosuccinate synthase

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1mg

￥625.00

500.00

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5mg

￥2825.00

2260.00

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10mg

￥5237.00

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25mg

￥12062.00

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货号: ajci20808
CAS: 5854-93-3
别名: 丙氨菌素; NSC-153353; SDX-102
分子式: C3H7N3O4
分子量: 149.1
纯度: >98%
溶解度: 100 mM HCl: 1 mg/ml,100 mM NaOH: 1 mg/ml,Water: 1 mg/ml
储存: Store at -20°C,unstable in solution, ready to use.
库存: 现货

Background

L-Alanosine (NSC-153353), an antibiotic from Streptomyces alanosinicus, has antineoplastic activity. L-Alanosine (NSC-153353) inhibits adenylosuccinate synthetase, which converts inosine monophospate (IMP) into adenylosuccinate. L-Alanosine (NSC-153353) blocks the common de novo purine biosynthesis pathway and, thereby, inhibits tumor cells with MTAP deficiency[1][2][3].

参考文献:
[1]. Efferth T, et al. Identification of gene expression profiles predicting tumor cell response to L-alanosine. Biochem Pharmacol. 2003 Aug 15;66(4):613-21.
[2]. Chitnis MP, et al. Antitumor effect of L-alanosine (NSC 153553) on sensitive and resistant sublines of murine leukemias. Tumori. 1984 Aug 31;70(4):317-20.
[3]. Tyagi AK, et al. Identification of the antimetabolite of L-alanosine, L-alanosyl-5-amino-4-imidazolecarboxylic acid ribonucleotide, in tumors and assessment of its inhibition of adenylosuccinate synthetase. Cancer Res. 1980 Dec;40(12):4390-7.