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  2. Bacterial
  3. Chrysomycin B
  • Chrysomycin B
Chrysomycin B的可视化放大

Chrysomycin B

An antibiotic with antitumor properties

原价
￥2825-6662
价格
￥ 2260-5330
Chrysomycin B的二维码

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  • 库存: 现货
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  • 货号: ajci20930
  • CAS: 83852-56-6
  • 别名: 金黄霉素B
  • 分子式: C27H28O9
  • 分子量: 496.5
  • 纯度: >98%
  • 溶解度: Soluble in DMSO
  • 储存: Store at -20°C
  • 库存: 现货

Background

Chrysomycin B is an antibiotic isolated from a strain of Streptomyces. It differs from its analog chrysomycin A by having a methyl, rather than vinyl, group in the 8-position of the chromophore. Like its analog, chrysomycin B suppresses the growth of transplantable tumors in mice, an effect that may be related to its ability to bind DNA. It also causes DNA damage in the human lung adenocarcinoma A549 cell line and inhibits topoisomerase II. Chrysomycin B is structurally very similar to gilvocarcin V, which promotes DNA cross-linking with histone 3 and GRP78 when photoactivated by near-UV light.

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