Bisindolylmaleimide X (hydrochloride)

A PKC inhibitor

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产品引用

货号: ajci20950
CAS: 145317-11-9
别名: BIM-X hydrochloride; Ro31-8425 hydrochloride
分子式: C26H24N4O2.HCl
分子量: 461
纯度: >98%
溶解度: Soluble in DMSO
储存: 4°C, protect from light
库存: 现货

Background

Bisindolylmaleimide X is a cell-permeable, reversible, ATP-competitive protein kinase C (PKC) inhibitor (IC50 = 15 nM, rat brain PKC). It has been shown to inhibit PKCα, βI, βII, γ, and ε with IC50 values of 8, 8, 14, 13, and 39 nM, respectively. It has also been identified as an inhibitor of Cdk2 (IC50 = 200 nM) and GSK3α/β. This compound has been used to activate mesenchymal stem cells, increase the surface expression of homing ligands that bind to intercellular adhesion molecule 1, and target delivery of these cells to sites of inflammation.

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Bisindolylmaleimide X (hydrochloride)

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