Arachidonoyl 2'-Chloroethylamide

A potent and selective CB1 receptor agonist

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库存: 现货

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5mg

￥662.00

530.00

- +
10mg

￥1212.00

970.00

- +
25mg

￥2825.00

2260.00

- +
50mg

￥4937.00

3950.00

- +

已选 0 种 0 瓶

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货号: ajci21112
CAS: 220556-69-4
别名: ACEA, 2'-chloro-AEA
分子式: C22H36ClNO
分子量: 366
纯度: >98%
溶解度: 25mg/mL in ethanol, 20mg/mL in DMSO, 30mg/mL in DMF
储存: Store at -80°C,protect from light
库存: 现货

Background

Arachidonoyl 2-chloroethylamide (ACEA) is a potent and selective cannabinoid (CB) receptor 1 agonist with Ki values of 1.4 and >2,000 nM for CB1 and CB2 receptors, respectively. In whole animal experiments, ACEA induces hypothermia in mice with the same efficacy as arachidonoyl ethanolamide , in spite of its higher affinity for the CB1 receptor. These data have been interpreted to indicate that ACEA may be a substrate for fatty acid amide hydrolase (FAAH), and thus only transiently available in whole animal experiments.

参考文献:
[1].Pertwee, R.G. Pharmacology of cannabinoid receptor ligands Curr. Med. Chem. 6(8), 635-664 (1999).
[2].Hillard, C.J., Manna, S., Greenberg, M.J., et al. Synthesis and characterization of potent and selective agonists of the neuronal cannabinoid receptor (CB1) J. Pharmacol. Exp. Ther. 289(3), 1427-1433 (1999).