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  • Ribavirin 5'-monophosphate (lithium salt)
Ribavirin 5'-monophosphate (lithium salt)的可视化放大

Ribavirin 5'-monophosphate (lithium salt)

A potent, broad-spectrum antiviral agent

原价
¥962-6012
价格
770-4810
Ribavirin 5'-monophosphate (lithium salt)的二维码

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  • 货号: ajci21560
  • CAS: 66983-94-6
  • 别名: 利巴韦林5'-单磷酸二锂盐
  • 分子式: C8H11N4O8P.2Li
  • 分子量: 336.1
  • 纯度: >98%
  • 溶解度: PBS (pH 7.2): 10 mg/ml
  • 储存: Store at -20°C
  • 库存: 现货

Background

Ribavirin 5'-monophosphate inhibits viral DNA and RNA replication in vitro via the strong competitive inhibition of inosine monophosphate dehydrogenase (IMPDH), with a reported Ki value of 270 nM, and thus inhibits guanosine triphosphate synthesis. This agent, a metabolite of the prodrug ribavirin , exhibits broad-spectrum antiviral activity, particularly against myxoviruses. The antiviral effects of ribavirin require conversion to the monophosphate form via adenosine kinase. The anti-HIV activity of ribavirin in cultured human lymphocytes, as well as the anti-influenza activity of this prodrug in MDCK cells, have been attributed to ribavirin 5'-monophosphate.

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