Ribavirin 5'-monophosphate (lithium salt)

A potent, broad-spectrum antiviral agent

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库存: 现货

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数量
500ug

￥962.00

770.00

- +
1mg

￥1700.00

1360.00

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5mg

￥6012.00

4810.00

- +

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Background

Ribavirin 5'-monophosphate inhibits viral DNA and RNA replication in vitro via the strong competitive inhibition of inosine monophosphate dehydrogenase (IMPDH), with a reported Ki value of 270 nM, and thus inhibits guanosine triphosphate synthesis. This agent, a metabolite of the prodrug ribavirin , exhibits broad-spectrum antiviral activity, particularly against myxoviruses. The antiviral effects of ribavirin require conversion to the monophosphate form via adenosine kinase. The anti-HIV activity of ribavirin in cultured human lymphocytes, as well as the anti-influenza activity of this prodrug in MDCK cells, have been attributed to ribavirin 5'-monophosphate.