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Milbemycin D is an insecticidal and anthelmintic antibiotic originally isolated from S.
Milbemycin D is an insecticidal and anthelmintic antibiotic originally isolated from S. hygroscopicus. It is toxic to third instar gypsy moth larvae with an LD50 value of 0.119 ug/g but not to sixth instar larvae. Milbemycin D eradicates A. caninum and is effective against T. canis in dogs when administered at doses of 0.05 and 0.1 mg/kg. It prevents D. immitis infection in dogs, but is not effective against T. vulpis or D. caninum. Milbemycin D also activates glutamate- (EC50 = 89 nM) and GABA-gated chloride channels.
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