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  • Bisindolylmaleimide I (hydrochloride)
Bisindolylmaleimide I (hydrochloride)的可视化放大

Bisindolylmaleimide I (hydrochloride)

A PKC inhibitor

原价
¥525-2600
价格
420-2080
Bisindolylmaleimide I (hydrochloride)的二维码

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  • 库存: 现货
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  • 货号: ajci21692
  • CAS: 176504-36-2
  • 别名: 3-[1-[3-(二甲基氨基)丙基]-1H-吲哚-3-基]-4-(1H-吲哚-3-基)-1H-吡咯-2,5-二酮单盐酸盐
  • 分子式: C25H24N4O2.HCl
  • 分子量: 449
  • 纯度: >98%
  • 溶解度: DMF: 10 mg/mL,DMSO: 16 mg/mL,DMSO:PBS(pH 7.2) (1:4): 0.2 mg/mL
  • 储存: Store at -20°C
  • 库存: 现货

Background

Bisindolylmaleimide I (BIM I) is a highly selective, cell-permeable, and reversible PKC inhibitor (Ki = 14 nM) that is structurally similar to the poorly selective PKC inhibitor staurosporine . It acts as a competitive inhibitor for the ATP binding site of PKC and shows high selectivity for PKCα, β1, β2, γ, δ, and ε isozymes. BIM I directly inhibits glycogen synthase kinase 3 (GSK3) in primary adipocyte lysates (IC50 = 360 nM) and in GSK3β immunoprecipitates derived from rat epididymal adipocytes (IC50 = 170 nM). It also competitively antagonizes the serotonin (5-HT) receptor subtype 5-HT3 with a Ki value of 61 nM.

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