Bisindolylmaleimide I (hydrochloride)

A PKC inhibitor

此产品仅用于科学研究，我们不为任何个人用途提供产品和服务

库存: 现货

可选规格

包装

价格

促销价

数量
500ug

￥525.00

420.00

- +
1mg

￥812.00

650.00

- +
5mg

￥2600.00

2080.00

- +

已选 0 种 0 瓶

金额: ￥0.00

首页收藏

货号: ajci21692
CAS: 176504-36-2
别名: 3-[1-[3-(二甲基氨基)丙基]-1H-吲哚-3-基]-4-(1H-吲哚-3-基)-1H-吡咯-2,5-二酮单盐酸盐
分子式: C25H24N4O2.HCl
分子量: 449
纯度: ＞98%
溶解度: DMF: 10 mg/mL,DMSO: 16 mg/mL,DMSO:PBS(pH 7.2) (1:4): 0.2 mg/mL
储存: Store at -20°C
库存: 现货

Background

Bisindolylmaleimide I (BIM I) is a highly selective, cell-permeable, and reversible PKC inhibitor (Ki = 14 nM) that is structurally similar to the poorly selective PKC inhibitor staurosporine . It acts as a competitive inhibitor for the ATP binding site of PKC and shows high selectivity for PKCα, β1, β2, γ, δ, and ε isozymes. BIM I directly inhibits glycogen synthase kinase 3 (GSK3) in primary adipocyte lysates (IC50 = 360 nM) and in GSK3β immunoprecipitates derived from rat epididymal adipocytes (IC50 = 170 nM). It also competitively antagonizes the serotonin (5-HT) receptor subtype 5-HT3 with a Ki value of 61 nM.

展开收缩

安捷凯在线客服

扫一扫加微信

信号通路

生命科学

有机化学

无机化学

材料科学

Bisindolylmaleimide I (hydrochloride)

Bisindolylmaleimide I (hydrochloride)详情

Background

安捷凯在线客服