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  • MZ1
MZ1的可视化放大

MZ1

A PROTAC that drives BRD4 degradation

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0-1740
MZ1的二维码

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  • 库存: 现货
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  • 货号: ajci21700
  • CAS: 1797406-69-9
  • 别名:
  • 分子式: C49H60ClN9O8S2
  • 分子量: 1002.6
  • 纯度: >98%
  • 溶解度: DMF: 30 mg/mL,DMSO: 30 mg/mL,Ethanol: 30 mg/mL,Ethanol:PBS (pH7.2) (1:7): 0.12 mg/mL
  • 储存: Store at -20°C
  • 库存: 现货

Background

MZ1 is a hybrid compound that drives the selective proteasomal degradation of bromodomain-containing protein 4 (BRD4). It is characterized as a proteolysis-targeting chimera (PROTAC) and contains JQ-1, which binds bromo- and extra-terminal (BET) proteins, linked to a ligand for the E3 ubiquitin ligase VHL. MZ1 induces the selective degradation of BRD4 in HeLa cells when used at 0.1-0.5 uM. At concentrations of 2-10 uM, MZ1 causes the removal of BRD2, BRD3, and BRD4. BRD protein removal is evident within four hours of adding MZ1 and persists for at least 48 hours, unless MZ1 is removed.

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