11-cis Retinal

An inverse agonist of opsin

原价

￥45137-45137

价格

￥ 36110-36110

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库存: 现货

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产品引用

货号: ajci21838
CAS: 564-87-4
别名: 11-cis Retinaldehyde, 11-cis Vitamin A aldehyde
分子式: C20H28O
分子量: 284.4
纯度: >98%
溶解度: Slightly Soluble in Chloroform, Methanol
储存: Store at -80°C
库存: 现货

Background

11-cis Retinal is a chromophore that binds to opsin in the mammalian visual system as an inverse agonist forming the inactive conformation of rhodopsin. When 11-cis retinal absorbs a photon of light, it isomerizes to form all-trans retinal beginning the phototransduction cycle, which is the basis for mammalian vision. A G121L mutation in opsin allows 11-cis retinal to bind as a partial agonist and activate rhodopsin in the absence of light. In a moth model of carotenoid deficiency-induced low visual sensitivity, 11-cis retinal application to compound eyes restored visual sensitivity almost completely.

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生命科学

有机化学

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材料科学

11-cis Retinal

11-cis Retinal详情

Background