2,3-dinor Prostaglandin E1

A minor metabolite of PGE1

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25ug

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货号: ajci21902
CAS: 7046-40-4
别名: 2,3-丁炔前列腺素E1
分子式: C18H30O5
分子量: 326.4
纯度: >98%
溶解度: DMF: >100 mg/ml,DMSO: >50 mg/ml,Ethanol: >50 mg/ml,PBS (pH 7.2): 1.67 mg/ml
储存: Store at -20°C
库存: 现货

Background

Prostaglandin E1 (PGE1) is not a major naturally occurring prostaglandin, but it is widely administered clinically for several indications including peripheral occlusive vascular disease, erectile dysfunction and in neonatal cardiology. The metabolism of PGE1 is normally initiated by oxidation at C-15, resulting in 13,14-dihydro-15-keto PGE1 as the major metabolite. However, inhibition of this pathway or saturation by excess substrate could theoretically lead to enhanced production of 2,3-dinor metabolites, including 2,3-dinor PGE1. The biological activity of 2,3-dinor PGE1 has not been published.?