CAY10640

A potent sEH inhibitor

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库存: 现货

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数量
1mg

￥900.00

720.00

- +
5mg

￥3512.00

2810.00

- +
10mg

￥5525.00

4420.00

- +

已选 0 种 0 瓶

金额: ￥0.00

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货号: ajci22016
CAS: 1208549-68-1
别名: sEHi, Soluble Epoxide Hydrolase Inhibitor
分子式: C17H20F3N3O3
分子量: 371.4
纯度: ＞98%
溶解度: DMF: 5 mg/ml,DMSO: 5 mg/ml,DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml,Ethanol: 2 mg/ml,PBS (pH 7.2): Isoluble
储存: Store at -20°C
库存: 现货

Background

Soluble epoxide hydrolase (sEH) inhibitors have important therapeutic use by increasing the in vivo concentration of EETs and other fatty acid epoxides, resulting in anti-inflammatory, antihypertensive, neuroprotective, and cardioprotective effects. CAY10640 is a 1-aryl-3-(1-acylpiperidin-4-yl)urea analog that inhibits recombinant human and mouse sEH with IC50 values both equal to 0.4 nM. CAY10640 demonstrates a 1,000-fold increase in potency compared to morphine in reducing hyperalgesia in an in vivo carrageenan-induced inflammatory pain model.

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生命科学

有机化学

无机化学

材料科学

CAY10640

CAY10640详情

Background

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