CAY10678

A mPGES-1 inhibitor

此产品仅用于科学研究，我们不为任何个人用途提供产品和服务

库存: 现货

可选规格

包装

价格

促销价

数量
1mg

￥1037.00

830.00

- +
5mg

￥2825.00

2260.00

- +
10mg

￥4025.00

3220.00

- +

已选 0 种 0 瓶

金额: ￥0.00

首页收藏

货号: ajci22050
CAS: 1268709-57-4
别名: mPGES-1 Inhibitor III
分子式: C23H34N4O
分子量: 382.5
纯度: >98%
溶解度: DMF: 15 mg/ml,DMSO: 5 mg/ml,Ethanol: 25 mg/ml,Ethanol:PBS (pH 7.2) (1:8): 0.1 mg/ml
储存: Store at -20°C
库存: 现货

Background

Microsomal prostaglandin E synthase-1 (mPGES-1) converts the COX product PGH2 into the biologically active PGE2. Like COX-2, the expression of mPGES-1 is induced in response to pro-inflammatory mediators, including LPS, IL-1β, and TNF-α. CAY10678 is a benzoimidazole that potently inhibits human and rat recombinant mPGES-1 (IC50 = 0.09 and 0.9 uM, respectively). It has minimal effects on COX-1, COX-2, PGIS, and hematopoietic PGDS at 50 μM but reduces lipocalin-type PGDS activity by 60% at this concentration. CAY10678 dose-dependently blocks PGE2 synthesis in isolated cells and whole blood treated with LPS or IL-1β. It also dose-dependently reduces PGE2 synthesis and cell recruitment during inflammation in mice.