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  • Acumapimod
Acumapimod的可视化放大

Acumapimod

An inhibitor of p38α MAPK

原价
¥912-7125
价格
730-5700
Acumapimod的二维码

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  • 货号: ajci22280
  • CAS: 836683-15-9
  • 别名: BCT197
  • 分子式: C22H19N5O2
  • 分子量: 385.42
  • 纯度: >98%
  • 溶解度: DMSO : ≥ 50 mg/mL (129.73 mM)
  • 储存: Store at -20°C
  • 库存: 现货

Background

Acumapimod (BCT197) is an orally active p38 MAP kinase inhibitor, with an IC50 of less than 1 uM for p38α.


Acumapimod is an inhibitor of p38α with an IC50 value of less than 1 uM.


BCT197 is an oral low-molecular-weight p38 inhibitor currently in development for the treatment of several inflammatory conditions, including chronic obstructive pulmonary disease (COPD). Intermittent short-term dosing of BCT197 (75 mg on days 1 and 6) shows a marked improvement in lung function in COPD patients[2].

参考文献:
[1]. Norman P, et al. Investigational p38 inhibitors for the treatment of chronic obstructive pulmonary disease. Expert Opin Investig Drugs. 2015 Mar;24(3):383-92.
[2]. De Buck S, et al. Population PK-PD Model for Tolerance Evaluation to the p38 MAP Kinase Inhibitor BCT197. CPT Pharmacometrics Syst Pharmacol. 2015 Dec;4(12):691-700.

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