AZD4635

An adenosine A2 receptor antagonist

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库存: 现货

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数量
5mg

￥937.00

750.00

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10mg

￥1325.00

1060.00

- +
25mg

￥2112.00

1690.00

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50mg

￥3225.00

2580.00

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100mg

￥4925.00

3940.00

- +

已选 0 种 0 瓶

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货号: ajci22340
CAS: 1321514-06-0
别名: HTL1071; AZD4635
分子式: C15H11ClFN5
分子量: 315.73
纯度: >98%
溶解度: DMSO : ≥ 83.3 mg/mL (263.83 mM);Water : < 0.1 mg/mL (insoluble)
储存: Store at -20°C
库存: 现货

Background

AZD4635 is a potent and selective, orally available adenosine A2A receptor (A2AR) antagonist. AZD4635 binds to human A2AR with a Ki of 1.7 nM and with > 30-fold selectivity over other adenosine receptors[1].

In the presence of 0.1, 1 and 10 μM adenosine, the IC50s of AZD4635 for inhibition of cAMP production are 0.79, 10.0 and 142.9 nM, respectively[1].

参考文献:
[1]. Alexandra Borodovsky, et al. Abstract 5580: Preclinical pharmacodynamics and antitumor activity of AZD4635, a novel adenosine 2A receptor inhibitor that reverses adenosine mediated T cell suppression. AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 5580.