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  • BLU-554
BLU-554的可视化放大

BLU-554

A potent inhibitor of FGFR4

原价
¥450-11012
价格
360-8810
BLU-554的二维码

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  • 货号: ajci22392
  • CAS: 1707289-21-1
  • 别名: BLU-554
  • 分子式: C24H24Cl2N4O4
  • 分子量: 503.38
  • 纯度: >98%
  • 溶解度: DMSO : ≥ 25 mg/mL (49.66 mM)
  • 储存: Store at -20°C
  • 库存: 现货

Background

BLU-554 is a potent fibroblast growth factor receptor 4 (FGFR4) inhibitor.


Fibroblast growth factor receptor 4 (FGFR-4) is a protein that in humans is encoded by the FGFR-4 gene. This protein is a member of the fibroblast growth factor receptor family, where amino acid sequence was highly conserved between members throughout evolution. FGFR family members 1-4 differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. The genomic organization of the FGFR-4 gene encompasses 18 exons. Although alternative splicing has been observed, there is no evidence that the C-terminal half of the Iglll domain of this protein varies between three alternate forms, as indicated for FGFR 1-3[1].

参考文献:
[1]. Neil Bifulco, et al. Inhibitors of the fibroblast growth factor receptor. PCT Int. Appl. (2015), WO 2015061572 A1 20150430.

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