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  2. HDAC (Histone deacetylases)
  3. HDAC8-IN-1
  • HDAC8-IN-1
HDAC8-IN-1的可视化放大

HDAC8-IN-1

An HDAC8 inhibitor

原价
￥987-7775
价格
￥ 790-6220
HDAC8-IN-1的二维码

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  • 库存: 现货
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  • 货号: ajci22620
  • CAS: 1417997-93-3
  • 别名: MDK-7933
  • 分子式: C22H19NO3
  • 分子量: 345.39
  • 纯度: >98%
  • 溶解度: DMSO : 150 mg/mL (434.29 mM)
  • 储存: Store at -20°C
  • 库存: 现货

Background

HDAC8-IN-1 is a HDAC8 inhibitor with an IC50 of 27.2 nM.


HDAC8-IN-1 is a HDAC8 inhibitor with an IC50 of 27.2 nM in cancer cell lines. HDAC8-IN-1 (compound 22 d) shows antiproliferative effects toward several human lung cancer cell lines (A549, H1299, and CL1-5); HDAC8-IN-1 exhibits cytotoxicity against human lung CL1-5 cells without significant cytotoxicity for normal IMR-90 cells[1].

参考文献:
[1]. Huang WJ, et al. Synthesis and biological evaluation of ortho-aryl N-hydroxycinnamides as potent histone deacetylase (HDAC) 8 isoform-selective inhibitors. ChemMedChem. 2012 Oct;7(10):1815-24.

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