R1487 Hydrochloride
An inhibitor of p38α MAPK
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包装价格促销价数量
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5mg￥825.00660.00- +
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10mg￥1225.00980.00- +
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25mg￥2400.001920.00- +
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50mg￥4012.003210.00- +
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100mg￥6462.005170.00- +
- 货号: ajci22850
- CAS: 449808-64-4
- 别名:
- 分子式: C19H19ClF2N4O3
- 分子量: 424.83
- 纯度: ＞98%
- 溶解度: DMSO : 20.83 mg/mL (49.03 mM);Water : < 0.1 mg/mL (insoluble)
- 储存: Store at -20°C
- 库存: 现货
Background
R1487 (Hydrochloride) is highly potent and highly selective inhibitors of p38α.target: p38α;R1487 (Hydrochloride) potently inhibits cytokine production in a variety of in vitro and in vivo models.[1]R1487 (Hydrochloride) inhibits production of TNFR by human monocytic cells (THP-1) and inhibits production of IL-1β in human whole blood (HWB) induced by LPS.[1]
参考文献:
[1]. Goldstein DM et al. Discovery of 6-(2,4-difluorophenoxy)-2-[3-hydroxy-1-(2-hydroxyethyl)propylamino]-8-methyl-8H-pyrido[2,3-d]pyrimidin-7-one (pamapimod) and 6-(2,4-difluorophenoxy)-8-methyl-2-(tetrahydro-2H-pyran-4-ylamino)pyrido[2,3-d]pyrimidin-7(8H)-one (R1487) as orally bioavailable and highly selective inhibitors of p38α mitogen-activated protein kinase. J Med Chem. 2011 Apr 14;54(7):2255-65.
