TH34 是一种 HDAC6/8/10 抑制剂，IC50 分别为 4.6 μM、1.9 μM 和 7.7 μM，对 HDAC1/2/3 具有高选择性。
TH34 is a potent HDAC6/8/10 inhibitor. TH34 induces DNA damage-mediated cell death in human high-grade neuroblastoma cell lines. The combination of TH34 with plasma-achievable concentrations of retinoic acid, a drug applied in neuroblastoma therapy, synergistically inhibits colony growth (combination index (CI)
Reference
[1].Kolbinger FR, Koeneke E, Ridinger J, Heimburg T, Müller M, Bayer T, Sippl W,?Jung M, Gunkel N, Miller AK, Westermann F, Witt O, Oehme I. The HDAC6/8/10?inhibitor TH34 induces DNA damage-mediated cell death in human high-grade?neuroblastoma cell lines. Arch Toxicol. 2018 Aug;92(8):2649-2664. doi:?10.1007/s00204-018-2234-8. Epub 2018 Jun 9. PubMed PMID: 29947893; PubMed Central?
PMCID: PMC6063332.
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