Angeli’s Salt
A classical nitroxyl (NO-) donor
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包装价格促销价数量
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5mg￥500.00400.00- +
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10mg￥975.00780.00- +
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50mg￥3750.003000.00- +
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100mg￥6375.005100.00- +
- 货号: ajci23098
- CAS: 13826-64-7
- 别名: 安吉里盐,Sodium α-oxyhyponitrite
- 分子式: Na2(ONNO2)
- 分子量: 122
- 纯度: ＞98%
- 溶解度: H20: 50 mg/ml,PBS (pH 7.2): 50 mg/ml
- 储存: Store at -20°C
- 库存: 现货
Background
Angeli’s salt is regarded as a classical nitroxyl (NO-) donor, but under certain conditions evolution of NO is also observed.1 It spontaneously dissociates in a pH-dependent, first-order process with a half-life of 2.3 minutes at 37°C (pH 7.4) to liberate 0.54 moles of NO per mole of parent compound.[1],[2]
Angeli盐被认为是一种经典的硝基氧基（NO-）供体，但在某些条件下也观察到NO的进化。1它在37°C（pH 7.4）下以2.3分钟的半衰期自发离解，每摩尔母体化合物释放0.54摩尔NO。[1] ，[2]
Reference:
[1]. Maragos, C.M., Morley, D., Wink, D.A., et al. Complexes of ?NO with nucleophiles as agents for the controlled biological release of nitric oxide. Vasorelaxant effects Journal of Medicinal Chemistry 34, 3242-3247 (1991).
[2]. Keefer, L.K., Nims, R.W., Davies, K.M., et al. “NONOates” (1-substituted diazen-1-ium-1,2-diolates) as nitric oxide donors: Convenient nitric oxide dosage forms Methods in Enzymology 268, 281-293 (1996
