N-acetyl-5-Aminosalicylic Acid

A metabolite of 5-ASA and sulfasalazine

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库存: 现货

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25mg

￥712.00

570.00

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50mg

￥1175.00

940.00

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100mg

￥2012.00

1610.00

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250mg

￥4300.00

3440.00

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货号: ajci64838
CAS: 51-59-2
别名: 5-乙酰氨基水杨酸
分子式: C9H9NO4
分子量: 195.2
纯度: >98%
溶解度: DMSO: slightly soluble,Methanol: slightly soluble
储存: Store at -20°C
库存: 现货

Background

N-acetyl-5-Aminosalicylic acid is a metabolite of the anti-inflammatory agent 5-aminosalicylic acid and its prodrug form, sulfasalazine . It is formed in the liver, intestinal lumen, and colonic epithelial cells via N-acetyltransferases. It reduces IFN-γ binding to colonic epithelial cells by 24% when used at a concentration of 10 mM. N-acetyl-5-Aminosalicylic acid (100 µM) scavenges 2,2-diphenyl-1-picrylhydrazyl radicals in a cell-free assay and inhibits base hydroxylation in DNA stimulated by hydroxy radicals. Unlike sulfasalazine, N-acetyl-5-aminosalicylic acid does not inhibit 15-hydroxy prostaglandin dehydrogenase (PGDH). Urinary levels of N-acetyl-5-aminosalicylic acid have been used as a marker of 5-ASA adherence in patients with inflammatory bowel disease.