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  • N-acetyl-5-Aminosalicylic Acid
N-acetyl-5-Aminosalicylic Acid的可视化放大

N-acetyl-5-Aminosalicylic Acid

A metabolite of 5-ASA and sulfasalazine

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¥712-4300
价格
570-3440
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  • 货号: ajci64838
  • CAS: 51-59-2
  • 别名: 5-乙酰氨基水杨酸
  • 分子式: C9H9NO4
  • 分子量: 195.2
  • 纯度: >98%
  • 溶解度: DMSO: slightly soluble,Methanol: slightly soluble
  • 储存: Store at -20°C
  • 库存: 现货

Background

N-acetyl-5-Aminosalicylic acid is a metabolite of the anti-inflammatory agent 5-aminosalicylic acid and its prodrug form, sulfasalazine . It is formed in the liver, intestinal lumen, and colonic epithelial cells via N-acetyltransferases. It reduces IFN-γ binding to colonic epithelial cells by 24% when used at a concentration of 10 mM. N-acetyl-5-Aminosalicylic acid (100 µM) scavenges 2,2-diphenyl-1-picrylhydrazyl radicals in a cell-free assay and inhibits base hydroxylation in DNA stimulated by hydroxy radicals. Unlike sulfasalazine, N-acetyl-5-aminosalicylic acid does not inhibit 15-hydroxy prostaglandin dehydrogenase (PGDH). Urinary levels of N-acetyl-5-aminosalicylic acid have been used as a marker of 5-ASA adherence in patients with inflammatory bowel disease.

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