2-Linoleoyl Glycerol

A congener of 2-arachidonoyl glycerol

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库存: 现货

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数量
500ug

￥212.00

170.00

- +
1mg

￥437.00

350.00

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5mg

￥1812.00

1450.00

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10mg

￥3187.00

2550.00

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货号: ajci65042
CAS: 3443-82-1
别名: 2LG
分子式: C21H38O4
分子量: 354.5
纯度: >98%
溶解度: DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 25 mg/ml,PBS (pH 7.2): 140 μ g/ml
储存: -80°C
库存: 现货

Background

2-Arachidonoyl glycerol (2-AG) has been isolated from porcine brain, and has been characterized as the natural endocannabinoid ligand for the CB1 receptor. The congener of 2-AG in which a linoleoyl group replaces the arachidonoyl group is 2-linoleoyl glycerol (2-LG), and this compound also appears in vivo in conjunction with 2-AG. Although the intrinsic activity of 2-LG is low, it potentiates the activity of other endocannabinoids, including 2-AG. This "entourage" effect has been attributed to blockade of the breakdown and reuptake pathways that normally function to reduce endocannabinoid levels rapidly upon release.