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  • DNA-PK Inhibitor IV
DNA-PK Inhibitor IV的可视化放大

DNA-PK Inhibitor IV

DNA-PK inhibitor IV is an inhibitor of DNA-dependent protein kinase (DNA-PK) with an IC50 value of 400 nM for the DNA-PK-dependent phosphorylation of a p53 peptide substrate.

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¥937-3025
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750-2420
DNA-PK Inhibitor IV的二维码

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  • 货号: ajci65364
  • CAS: 70362-07-1
  • 别名: 2-羟基-4-N-吗啉基苯甲醛
  • 分子式: C11H13NO3
  • 分子量: 207.2
  • 纯度: >98%
  • 溶解度: DMF: 33 mg/ml,DMSO: 33 mg/ml,DMSO:PBS (pH 7.2) (1:6): 0.14 mg/ml
  • 储存: Store at -20°C
  • 库存: 现货

Background

DNA-PK inhibitor IV is an inhibitor of DNA-dependent protein kinase (DNA-PK) with an IC50 value of 400 nM for the DNA-PK-dependent phosphorylation of a p53 peptide substrate. It also inhibits the phosphatidylinositol 3-kinase (PI3K) isoforms p110β, p110δ, and p110γ (IC50s = 2.8, 5.1, and 37 nM, respectively) but not p110α (IC50 = ~10 µM) or class II PI3Ks, PI4Kβ, ATM, ATR, mTOR, CK2, or GRK2 (IC50s = >50 µM). It enhances radiation-induced cytotoxicity of HCT116 cells when used at a concentration of 100 µM.

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