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6α-Prostaglandin I1的可视化放大

6α-Prostaglandin I1

A potent inhibitor of ADP-induced platelet aggregation

原价
￥1062-8387
价格
￥ 850-6710
6α-Prostaglandin I1的二维码

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  • 库存: 现货
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  • 货号: ajci65412
  • CAS: 62777-90-6
  • 别名: 6αPGI1, 5,6αdihydro PGI2
  • 分子式: C20H34O5
  • 分子量: 354.5
  • 纯度: >98%
  • 溶解度: DMF: >10 (from (6b-PGI1),DMSO: >5 (from (6b-PGI1),Ethanol: >20 mg/ml (from (6b-PGI1),PBS pH 7.2: >80 μ g (from (6b-PGI1)
  • 储存: Store at -20°C
  • 库存: 现货

Background

6α-Prostaglandin I1 (6α-PGI1) is a stable Prostaglandin I2 (PGI2) analog resistant to hydrolysis in aqueous solutions. 6α-PGI1 promotes cyclic AMP accumulation in human thyroid slices and cells in a concentration dependent manner. However, it is about 10-fold less potent than the β-isomer and 100-fold less potent than PGI2 in eliciting the response. 6α-PGI1 exhibits an IC50 of 350 ng/ml for inhibition of ADP-induced platelet aggregation, which is nearly 900-fold higher than that observed for PGI2 (0.4 ng/ml).

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