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- Cyclooxygenase (COX)
- Prostaglandin E3
Prostaglandin E3
Decreases IOP in rabbits
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50ug￥3025.002420.00- +
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100ug￥5750.004600.00- +
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500ug￥17857.0014285.00- +
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- 货号: ajci65464
- CAS: 802-31-3
- 别名: PGE3
- 分子式: C20H30O5
- 分子量: 350.5
- 纯度: ＞98%
- 溶解度: DMF: ＞100 mg/ml；DMSO: ＞100 mg/ml；Ethanol: ＞100 mg/ml；PBS (pH 7.2): ＞5 mg/ml
- 储存: Store at -20°C
- 库存: 现货
Background
Prostaglandin E3 (PGE3) is formed via the cyclooxygenase (COX) metabolism of eicosapentaenoic acid. [1]? In human ocular tissue, it comprises 2.4% of the COX products formed. [1]? When applied to the eyes of a rabbit, a 1 µg dose of PGE3 decreases intraocular pressure from 21 mmHg to about 17 mmHg.[2]?
Reference:
[1]. Kulkarni, P.S., and Srinivasan, B.D. Eicosapentaenoic acid metabolism in human and rabbit anterior uvea. Prostaglandins 31(6), 1159-1164 (1986).
[2]. Kulkarni, P.S., and Srinivasan, B.D. Prostaglandins E3 and D3 lower intraocular pressure. Investigative Ophthalmology & Visual Science 26, 1178-1182 (1985).
