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安捷凯生物医药，安捷凯化学
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  2. Reactive oxygen species (ROS)
  3. CAY10706
  • CAY10706
CAY10706的可视化放大

CAY10706

A TrxR inhibitor

原价
￥2587-16025
价格
￥ 2070-12820
CAY10706的二维码

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  • 库存: 现货
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  • 货号: ajci65542
  • CAS: 1881270-27-4
  • 别名:
  • 分子式: C19H20N2O3
  • 分子量: 324.4
  • 纯度: >98%
  • 溶解度: DMF: 1 mg/ml
  • 储存: Store at -20°C
  • 库存: 现货

Background

CAY10706 is a ligustrazine-curcumin hybrid that promotes intracellular reactive oxygen species accumulation preferentially in lung cancer cells. It has been shown to inhibit the proliferation of drug-sensitive (A549 (IC50 = 2.19 µM), SPC-A-1 (IC50 = 3.12 µM), LTEP-G-2 (IC50 = 2.88 µM)) and drug-resistant (A549/DDP (IC50 = 0.6 µM)) lung cancer cells but demonstrates little effect on non-tumor lung epithelial-like cells (HBE (IC50 = 21.34 µM)). CAY10706 can suppress the thioredoxin reductase system and inhibit the NF-κB, Akt, and ERK signaling.

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