Heat Shock Protein Inhibitor II

Prevents the synthesis of inducible heat shock proteins

此产品仅用于科学研究，我们不为任何个人用途提供产品和服务

库存: 现货

可选规格

包装

价格

促销价

数量
5mg

￥1550.00

1240.00

- +
10mg

￥2800.00

2240.00

- +
25mg

￥6162.00

4930.00

- +

已选 0 种 0 瓶

金额: ￥0.00

首页收藏

货号: ajci65690
CAS: 1859-42-3
别名: Hsp Inhibitor II, KNK 423
分子式: C12H11NO3
分子量: 217.2
纯度: >98%
溶解度: DMF: 10 mg/ml,DMSO: 10 mg/ml,DMSO:PBS (pH 7.2)(1:5): 0.1 mg/ml
储存: Store at -20°C
库存: 现货

Background

Heat shock protein (Hsp) inhibitor II is the active form of Hsp inhibitor I and a benzylidene lactam compound that prevents the synthesis of inducible Hsps, such as Hsp105, Hsp72, and Hsp40. Hsp inhibitor II decreases Hsp72 synthesis in vivo and reduces thermotolerance of tumors in SCC VII tumor-containing mice. At 100 µM, it inhibits the development of thermotolerance in COLO 320 DM cells. Inhibition of Hsp70 with Hsp inhibitor II in combination with amphotericin B increases susceptibility of AmB-susceptible (MICs = 0.058 versus 0.27 µg/ml for combined and AmB alone, respectively) and AmB-resistant (MICs = 21.33 versus >32 µg/ml for combined and AmB alone, respectively) strains of A. fumigatus.