WHI-P258

A negative control for JAK3 inhibition

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库存: 现货

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促销价

数量
2mg

￥375.00

300.00

- +
5mg

￥700.00

560.00

- +
10mg

￥1100.00

880.00

- +
25mg

￥2400.00

1920.00

- +
50mg

￥4200.00

3360.00

- +
100mg

￥6150.00

4920.00

- +
200mg

￥0.00

0.00

- +
500mg

￥0.00

0.00

- +

已选 0 种 0 瓶

金额: ￥0.00

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Background

WHI-P258 is a quinazoline compound that modeling studies suggested would bind to the active site of JAK3 with an estimated K_i value of 72 ?M.¹ However, it is inactive at JAK3 (IC₅₀ = >300 ?M) and has been used as a negative control for structurally similar compounds that inhibit platelet aggregation and herpes simplex virus 1 (HSV-1) replication.^2,3

1.Sudbeck, E.A., Liu, X.P., Narla, R.K., et al.Structure-based design of specific inhibitors of Janus kinase 3 as apoptosis-inducing antileukemic agentsClin. Cancer Res.5(6)1569-1582(1999) 2.Yakota, S.-i., Yokosawa, N., Okabayashi, T., et al.Induction of suppressor of cytokine signaling-3 by herpes simplex virus type 1 confers efficient viral replicationVirology338(1)173-181(2005) 3.Tibbles, H.E., Vassilev, A., Wendorf, H., et al.Role of a JAK3-dependent biochemical signaling pathway in platelet activation and aggregationJ. Biol. Chem.276(21)17815-17822(2001)