A flavonoid with antioxidative and osteogenic activities
Neoeriocitrin is a flavonoid that has been found in C. paradisi and has antioxidative and osteogenic activities. It inhibits the production of 2,2-diphenyl-1-picrylhydrazyl radicals by 17.2% and the formation of superoxide radicals by 48.3% in cell-free assays, as well as decreases the rate of LDL oxidation ex vivo in isolated hamster plasma. Neoeriocitrin (2 µg/ml) increases proliferation of MC3T3-E1 osteoblast percursor cells and reverses the antiproliferative effect of the MEK1 inhibitor PD 98059 . It also increases the expression of the osteogenic differentiation markers Runx2, Type 1 collagen, and osteocalcin.
动态评分
0.0