An anti-inflammatory HMGB inhibitor
Inflachromene is an anti-inflammatory agent that directly binds high mobility group protein 1 (HMGB1) and HMGB2 and reduces their cytoplasmic accumulation in microglial cells.[1] It is functional in vivo, downregulating proinflammatory functions of HMGB proteins and reducing neuronal damage. Inflachromene also ameliorates inflammatory pathogenesis in a mouse model of sepsis.[2]
Reference:
[1]. Lee, S., Nam, Y., Koo, J.Y., et al. A small molecule binding HMGB1 and HMGB2 inhibits microglia-mediated neuroinflammation. Nat. Chem. Biol. 10(12), 1055-1060 (2014).
[2]. Cho, W., Koo, J.Y., Park, Y., et al. Treatment of sepsis pathogenesis with high mobility group box protein 1-regulating anti-inflammatory agents. J. Med. Chem. 60(1), 170-179 (2017).
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