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Background:
JWH 116 is a synthetic cannabinoid (CB) receptor ligand from the naphthoylindole family. It is the indole 2-ethyl derivative of the related compound JWH 018 and has a Ki value of 52 nM for the CB1 receptor.[1]
Reference:
[1]. Huffman, J.W., Mabon, R., Wu, M.J., et al. 3-indolyl-1-naphthylmethanes: New cannabimimetic indoles provide evidence for aromatic stacking interactions with the CB1 cannabinoid receptor. Bioorganic & Medicinal Chemistry 11, 539-549 (2003).
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