Necrostatin-5

A RIP1 kinase inhibitor

原价

￥450-2012

价格

￥ 360-1610

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库存: 现货

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产品引用

货号: ajci66470
CAS: 337349-54-9
别名: 2-[[3,4,5,6,7,8-六氢-3-(4-甲氧基苯基)-4-氧代[1]苯并噻吩并[2,3-D]嘧啶-2-基]硫代]-乙腈
分子式: C19H17N3O2S2
分子量: 383.5
纯度: >98%
溶解度: DMSO: 10 mg/ml
储存: Store at -20°C
库存: 现货

Background

Necroptosis is a regulated caspase-independent cell death mechanism that results in morphological features resembling necrosis. Serine/threonine kinase activity of the death domain receptor-associated molecule RIP1 is thought to be essential for Fas ligand-induced and tumor necrosis factor-α (TNF-α) induced necrosis. Necrostatin-5 is a selective allosteric inhibitor of RIP1 kinase that prevents the death of TNF-α-treated FADD-deficient Jurkat cells with an EC50 value of 240 nM.

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信号通路

生命科学

有机化学

无机化学

材料科学

Necrostatin-5

Necrostatin-5详情

Background