Necrostatin-5
A RIP1 kinase inhibitor
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5mg￥450.00360.00- +
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25mg￥2012.001610.00- +
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- 货号: ajci66470
- CAS: 337349-54-9
- 别名: 2-[[3,4,5,6,7,8-六氢-3-(4-甲氧基苯基)-4-氧代[1]苯并噻吩并[2,3-D]嘧啶-2-基]硫代]-乙腈
- 分子式: C19H17N3O2S2
- 分子量: 383.5
- 纯度: ＞98%
- 溶解度: DMSO: 10 mg/ml
- 储存: Store at -20°C
- 库存: 现货
Background
Necroptosis is a regulated caspase-independent cell death mechanism that results in morphological features resembling necrosis. Serine/threonine kinase activity of the death domain receptor-associated molecule RIP1 is thought to be essential for Fas ligand-induced and tumor necrosis factor-α (TNF-α) induced necrosis. Necrostatin-5 is a selective allosteric inhibitor of RIP1 kinase that prevents the death of TNF-α-treated FADD-deficient Jurkat cells with an EC50 value of 240 nM.
