安捷凯生物医药
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  • BI-6C9
BI-6C9的可视化放大

BI-6C9

An inhibitor of tBid-mediated apoptosis

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BI-6C9的二维码
  • 库存: 现货
可选规格
  • 包装
    价格
    促销价
    数量
  • 1mg
    ￥612.00
    490.00
    - +
  • 5mg
    ￥2212.00
    1770.00
    - +
  • 10mg
    ￥3650.00
    2920.00
    - +
已选 0 种 0 瓶
金额: ￥0.00
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使用我司产品发表的文章

  • 货号: ajci66746
  • CAS: 791835-21-7
  • 别名:
  • 分子式: C23H25N3O4S2
  • 分子量: 471.6
  • 纯度: >98%
  • 溶解度: 0.5mg/mL in ethanol, 30mg/mL in DMSO or in DMF
  • 储存: Store at -20°C
  • 库存: 现货

Background

BH3-interacting domain (Bid) is cleaved by caspase-8 to produce the truncated protein tBid, which facilitates cytochrome c release from mitochondria and drives apoptosis. BI-6C9 is an inhibitor of tBid (Kd = 20 µM), blocking the release of both cytochrome c and second mitochondria-derived activator of caspase from mitochondria. It prevents apoptosis in neurons treated with glutamate or oxygen-glucose deprivation. BI-6C9 (10 µM) also inhibits the nuclear translocation of apoptosis-inducing factor AIF, preventing the death of ovarian OVCAR-3 cancer cells induced by IFN-α2a.

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