Benzisoxazole Hsp90 Inhibitor

Hsp90 chaperone inhibitor

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库存: 现货

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数量
1mg

￥2012.00

1610.00

- +
5mg

￥9050.00

7240.00

- +
10mg

￥15937.00

12750.00

- +

已选 0 种 0 瓶

金额: ￥0.00

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货号: ajci67306
CAS: 1012788-65-6
别名: BHI
分子式: C19H20ClN3O4
分子量: 389.8
纯度: >98%
溶解度: DMF: 20 mg/ml,DMSO: 20 mg/ml,Ethanol: 25 mg/ml,Ethanol:PBS (pH 7.2) (1:10): 0.1 mg/ml
储存: Store at -20°C
库存: 现货

Background

Heat shock protein 90 (Hsp90) is a molecular chaperone that modulates intracellular signaling and protein folding, trafficking, and turnover. Inhibitors of Hsp90, such as geldanamycin, have shown promise as anti-tumor agents. Benzisoxazole Hsp90 inhibitor binds the N-terminal domain of Hsp90, efficiently displacing geldanamycin from the ATP binding site (IC50 = 30 nM). In addition, Benzisoxazole Hsp90 inhibitor inhibits the proliferation of several cancer cell lines (IC50 ~ 0.28 μM), promotes the degradation of the Hsp90 client proteins Her-2 and androgen receptor, and has no effect on a variety of kinases.