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  • Benzisoxazole Hsp90 Inhibitor
Benzisoxazole Hsp90 Inhibitor的可视化放大

Benzisoxazole Hsp90 Inhibitor

Hsp90 chaperone inhibitor

原价
¥2012-15937
价格
1610-12750
Benzisoxazole Hsp90 Inhibitor的二维码

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  • 货号: ajci67306
  • CAS: 1012788-65-6
  • 别名: BHI
  • 分子式: C19H20ClN3O4
  • 分子量: 389.8
  • 纯度: >98%
  • 溶解度: DMF: 20 mg/ml,DMSO: 20 mg/ml,Ethanol: 25 mg/ml,Ethanol:PBS (pH 7.2) (1:10): 0.1 mg/ml
  • 储存: Store at -20°C
  • 库存: 现货

Background

Heat shock protein 90 (Hsp90) is a molecular chaperone that modulates intracellular signaling and protein folding, trafficking, and turnover. Inhibitors of Hsp90, such as geldanamycin, have shown promise as anti-tumor agents. Benzisoxazole Hsp90 inhibitor binds the N-terminal domain of Hsp90, efficiently displacing geldanamycin from the ATP binding site (IC50 = 30 nM). In addition, Benzisoxazole Hsp90 inhibitor inhibits the proliferation of several cancer cell lines (IC50 ~ 0.28 μM), promotes the degradation of the Hsp90 client proteins Her-2 and androgen receptor, and has no effect on a variety of kinases.

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