FzM1

An allosteric ligand of Frizzled4

此产品仅用于科学研究，我们不为任何个人用途提供产品和服务

库存: 现货

可选规格

包装

价格

促销价

数量
500ug

￥300.00

240.00

- +
1mg

￥575.00

460.00

- +
5mg

￥1012.00

810.00

- +

已选 0 种 0 瓶

金额: ￥0.00

首页收藏

货号: ajci67310
CAS: 1680196-54-6
别名: Frizzled M1
分子式: C21H16N2O2S
分子量: 360.4
纯度: >98%
溶解度: DMF: 12 mg/ml,DMF:PBS (pH 7.2)(1:3): 0.2 mg/ml,DMSO: 10 mg/ml
储存: Store at -20°C
库存: 现货

Background

Wnt signaling proteins are small secreted proteins that are active in embryonic development, tissue homeostasis, and tumorigenesis. Wnt proteins initiate cell signaling by binding Frizzled (Fz) receptors, a family of G protein-coupled receptors. FzM1 is an allosteric ligand of Fz4. At 10 µM, it inhibits nuclear translocation of β-catenin in U87MG glioma cells treated with lithium chloride, a GSK3 inhibitor that enhances the Wnt canonical signaling pathway. FzM1 impairs the ability of U87MG cells to form neurospheres in culture and stimulates the differentiation of Caco-2 epithelial colorectal adenocarcinoma cells.