现货大促销，价格低至8折起，量大更优惠，详细咨询客服
安捷凯生物医药，安捷凯化学
全部分类
全部分类
  1. 首页
  2. Wnt
  3. FzM1
  • FzM1
FzM1的可视化放大

FzM1

An allosteric ligand of Frizzled4

原价
￥300-1012
价格
￥ 240-810
FzM1的二维码

所有产品仅用于科学研究，我们不为任何个人用途提供产品和服务

询价有惊喜，量大更优惠 点击这里给我发消息

  • 库存: 现货
可选包装 >>>
首页
  • 货号: ajci67310
  • CAS: 1680196-54-6
  • 别名: Frizzled M1
  • 分子式: C21H16N2O2S
  • 分子量: 360.4
  • 纯度: >98%
  • 溶解度: DMF: 12 mg/ml,DMF:PBS (pH 7.2)(1:3): 0.2 mg/ml,DMSO: 10 mg/ml
  • 储存: Store at -20°C
  • 库存: 现货

Background

Wnt signaling proteins are small secreted proteins that are active in embryonic development, tissue homeostasis, and tumorigenesis. Wnt proteins initiate cell signaling by binding Frizzled (Fz) receptors, a family of G protein-coupled receptors. FzM1 is an allosteric ligand of Fz4. At 10 µM, it inhibits nuclear translocation of β-catenin in U87MG glioma cells treated with lithium chloride, a GSK3 inhibitor that enhances the Wnt canonical signaling pathway. FzM1 impairs the ability of U87MG cells to form neurospheres in culture and stimulates the differentiation of Caco-2 epithelial colorectal adenocarcinoma cells.

动态评分

0.0

没有评分数据
没有评价数据
一键回到顶部
展开 收缩
安捷凯在线客服