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  2. nAChR/nAChRs (nicotinic acetylcholine receptors)
  3. (±)-Nornicotine
  • (±)-Nornicotine
(±)-Nornicotine的可视化放大

(±)-Nornicotine

An active metabolite of nicotine and nAChR agonist

原价
￥375-3237
价格
￥ 300-2590
(±)-Nornicotine的二维码

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  • 库存: 现货
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  • 货号: ajci67594
  • CAS: 5746-86-1
  • 别名: 3-(吡咯烷-2-基)吡啶
  • 分子式: C9H12N2
  • 分子量: 148.2
  • 纯度: >98%
  • 溶解度: DMF: 50 mg/ml,DMSO: 30 mg/ml,Ethanol: 50 mg/ml,PBS (pH 7.2): 1 mg/ml
  • 储存: Store at 2-8°C
  • 库存: 现货

Background

(±)-Nornicotine is a metabolite of nicotine that acts as a neuronal nicotinic acetylcholine receptor (nAChR) agonist. The α6 and α7 subunit-containing neuronal nAChRs are particularly responsive to nornicotine with EC50 values of approximately 4 and 17 µM, respectively, when expressed in Xenopus oocytes. Nornicotine promotes cell migration and destabilizes cell-cell junctions in an endothelial cell line. It is generally thought to be free from abuse potential, but it has been self-administered by rats. It can be detected in urine.

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