10'-Desmethoxystreptonigrin

An antibiotic

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库存: 现货

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数量
500ug

￥3775.00

3020.00

- +
2.5mg

￥12150.00

9720.00

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货号: ajci67972
CAS: 136803-89-9
别名: 10-去甲氧基链黑霉素
分子式: C24H20N4O7
分子量: 476.4
纯度: >98%
溶解度: DMF: soluble,DMSO: soluble,Ethanol: soluble,Methanol: soluble
储存: Store at -20°C
库存: 现货

Background

10'-Desmethoxystreptonigrin is an antibiotic originally isolated from Streptomyces and a derivative of the antibiotic streptonigrin. It is active against a variety of bacteria, including S. aureus, S. faecalis, E. coli, K. pneumoniae, and P. vulgaris (MICs = 0.4, 1.6, 3.1, 3.1 and 0.4 µg/ml, respectively). 10'-Desmethoxystreptonigrin is cytotoxic to HCT116 colon and A2780 ovarian cancer cells (IC50s = 0.004 and 0.001 µg/ml, respectively), as well as HCT116 cells resistant to etoposide and teniposide and cisplatin-resistant A2780 cells (IC50s = 0.003, 0.001, and 0.01 µg/ml, respectively). 10'-Desmethoxystreptonigrin is also an inhibitor of p21ras farnesylation (IC50 = 21 nM).