1-Methylnicotinamide (chloride)

A metabolite of nicotinamide

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库存: 现货

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100mg

￥387.00

310.00

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500mg

￥987.00

790.00

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1g

￥1537.00

1230.00

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货号: ajci68242
CAS: 1005-24-9
别名: 3-氨基甲酰-1-甲基氯化吡啶,1-Methylnicotinamide chloride; N-methylnicotinamide chloride
分子式: C7H9N2O?Cl
分子量: 172.6
纯度: >98%
溶解度: 10mg/ml in PBS (pH 7.2)
储存: Store at -20°C
库存: 现货

Background

Nicotinamide is a precursor of NAD and NADP , which serve essential functions in modulating cellular redox status and controlling signaling and transcriptional events. 1-Methylnicotinamide (MNA) is a primary metabolite of nicotinamide produced by the action of nicotinamide N-methyltransferase . It demonstrates antithrombotic and anti-inflammatory properties through direct action on the endothelium by a mechanism involving the prostacyclin pathway and by improving nitric oxide bioavailability. Aggressive cancer cell lines are reported to have higher levels of MNA due to increased NNMT-directed transfer of methyl groups from S-adenosyl-L-methionine to nicotinamide, implicating a role for MNA in cancer cell metabolism.