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A cell-permeable analog of DAG
OAG is a cell-permeable analog of the PKC-activating second messenger DAG. It activates PKC in platelets, resulting in the phosphorylation of a 40 kDa protein. OAG is metabolized to its corresponding phosphatidic acid (1-oleoyl-2-acetyl-3-phosphoglycerol), most likely through the action of a diglycerol kinase.[1]
Reference:
[1]. Nishizuka, Y. The role of protein kinase C in cell surface signal transduction and tumour promotion. Nature 308, 693-697 (1984).
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