1-Stearoyl-2-Arachidonoyl-sn-Glycerol

An activator of PKC and Ras

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库存: 现货

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5mg

￥825.00

660.00

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10mg

￥1487.00

1190.00

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25mg

￥3350.00

2680.00

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货号: ajci68330
CAS: 65914-84-3
别名: 1-硬脂酰-2-花生酰-SN-甘油
分子式: C41H72O5
分子量: 645
纯度: >98%
溶解度: DMF: 0.2 mg/ml,DMSO: 0.3 mg/ml,Ethanol: 10 mg/ml,PBS (pH 7.2): 0.1 mg/ml
储存: Store at -80°C; protect from light
库存: 现货

Background

Many protein kinase C (PKC) isoforms require activation via second messengers including Ca2+, diacylglycerol (DAG), and/or a phospholipid to phosphorylate target proteins and they initiate a variety of important signalling cascades. 1-Stearoyl-2-arachidonoyl-sn-glycerol (SAG) is a DAG that contains the ω-6 polyunsaturated fatty acid arachidonic acid in the sn-2 position and stearic acid in the sn-1 position of the glycerol backbone. It can potently activate PKCα, PKCε, and PKCδ at nM concentrations. Independent of PKC signalling, SAG competitively binds to the Ras activator RasGRP with a Ki value of 4.49 µM in Jurkat T-cells.