BT2

An Mcl-1 inhibitor

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库存: 现货

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促销价

数量
1mg

￥212.00

170.00

- +
5mg

￥550.00

440.00

- +
10mg

￥875.00

700.00

- +
50mg

￥2400.00

1920.00

- +

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金额: ￥0.00

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Background

3,6-dichloro-benzo[b]thiophene-2-Carboxylic acid is an inhibitor of myeloid cell leukemia 1 (Mcl-1) with a K_i value of 59 μM for binding of FITC-Mcl-1-BH2 peptide binding to Mcl-1.¹ It has been used as a building block in the synthesis of inhibitors of Mcl-1, the toll-like receptor 3/double-stranded RNA (TLR3/dsRNA) complex, and D-amino acid oxidase (DAO).^1,2,3

1.Friberg, A., Vigil, D., Zhao, B., et al.Discovery of potent myeloid cell leukemia 1 (Mcl-1) inhibitors using fragment-based methods and structure-based designJ. Med. Chem.56(1)15-30(2013) 2.Cheng, K., Wang, X., and Yin, H.Small-molecule inhibitors of the TLR3/dsRNA complexJ. Am. Chem. Soc.133(11)3764-3767(2011) 3.Katane, M., Osaka, N., Matsuda, S., et al.Identification of novel D-amino acid oxidase inhibitors by in silico screening and their functional characterization in vitroJ. Med. Chem.56(5)1894-1907(2013)