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  • Ansatrienin B
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Ansatrienin B

An ansamycin antibiotic and antifungal

原价
¥5950-22875
价格
4760-18300
Ansatrienin B的二维码

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  • 货号: ajci69874
  • CAS: 82189-04-6
  • 别名: 安三烯菌素B,Mycotrienin II
  • 分子式: C36H50N2O8
  • 分子量: 638.8
  • 纯度: >98%
  • 溶解度: DMF: Soluble,DMSO: Soluble,Ethanol: Soluble,Methanol: Soluble
  • 储存: Store at -20°C
  • 库存: 现货

Background

Ansatrienin B is an ansamycin antibiotic and antifungal agent first isolated from S. collinus and S. rishiriensis., In fetal rat long bones, it is an inhibitor of parathyroid hormone-induced calcium release (IC50 = 21 nM), which is a measure of bone resorption, and pp60c-src kinase (IC50 = 50 nM). It is an inhibitor of translation at the protein synthesis stage by specific inhibition of L-leucine incorporation (IC50 = 58 nM in A549 cells). It also inhibits TNF-α-induced expression of intercellular adhesion molecule-1 (ICAM-1; IC50 = 300 nM). Early in vitro studies showed that ansatrienin B potentiates the chemotherapeutic action of 5-fluorouracil , cisplatin , bleomycin , mitomycin C , and 6-mercaptopurine. Ansatrienin B is a hydroquinone form of ansatrienin A .

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