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  2. CXCRs (CXC chemokine receptors)
  3. Antileukinate
  • Antileukinate
Antileukinate的可视化放大

Antileukinate

A CXCR2 chemokine receptor antagonist

原价
￥1537-11450
价格
￥ 1230-9160
Antileukinate的二维码

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  • 库存: 现货
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  • 货号: ajci69876
  • CAS: 138559-60-1
  • 别名:
  • 分子式: C45H66N18O7S
  • 分子量: 1003.2
  • 纯度: >98%
  • 溶解度: DMF: 1 mg/ml,DMSO: 5 mg/ml,PBS (pH 7.2): 2 mg/ml
  • 储存: Store at -20°C
  • 库存: 现货

Background

Antileukinate is a synthetic hexapeptide with an acetylated amino terminus and an amidated carboxyl terminus that inhibits the binding of CXC chemokines to the chemokine receptor CXCR2. It inhibits IL-8 binding to neutrophils (Ki = 2.7-13 µM), prevents neutrophil chemotaxis and β-glucuronidase release, and blocks IL-8-induced skin edema in rabbits. At 53 mg/kg, antileukinate has been shown to protect mice against acute pancreatitis and associated lung injury.

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