Antimycin A3

此产品仅用于科学研究，我们不为任何个人用途提供产品和服务

可选规格

包装

价格

促销价

数量
1mg

￥3384.00

2707.00

- +
5mg

￥14677.00

11741.00

- +

已选 0 种 0 瓶

金额: ￥0.00

首页收藏

Antimycin A3 is a component of the antimycin A antibiotic complex that is more polar than antimycin A1 and antimycin A2 but not antimycin A4.

货号：ajci69880
CAS：522-70-3
分子式：C26H36N2O9
分子量：520.6
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Antimycin A3 is a component of the antimycin A antibiotic complex that is more polar than antimycin A1 and antimycin A2 but not antimycin A4 . Antimycin A3 binds to the Q(inner) site of mitochondrial complex III (cytochrome bc1) and inhibits mitochondrial respiration (IC50 = 38 nM in isolated rat liver mitochondria). It also inhibits ATP-citrate lyase with a Ki value of 60.1 µM, and it stimulates the production of reactive oxygen species. In molecular modeling studies, antimycin binds to a mutant form of Bcl-2 (hBcl-2δ22) and has a Kd value of 0.82 µM for binding to a recombinant mutant form of Bcl-2 (rhBcl-2δ22) in an isothermal calorimetry assay.